This page was prepared by Lynn Kash, RN, Internet Nursing Guide
Pennsylvania Nurses,Emergency Department
http://www.nursefriendly.com/kash/

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zidovudine (AZT, Retrovir) a Simple FactSheet from the AIDS Treatment Data Network:"Zidovudine, trade name Retrovir (also known as AZT or ZDV) was the first drug approved for the treatment of HIV. Retrovir is an anti-HIV treatment in a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs). The body breaks down these drugs into chemicals that stop HIV from infecting uninfected cells in the body, but they do not help cells that have already been infected with the virus. As people with HIV lose T4 cells - one of the immune systems main defenses - they become more likely to get infections and illnesses."
http://www.atdn.org/simple/zido.html

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AZT (Retrovir), What Is AZT, The Body.com:"AZT (Retrovir®) is a drug used for antiviral therapy. It is manufactured by GlaxoSmithKline. AZT is also known as azido-deoxythymidine, zidovudine or ZDV.

AZT was the first drug approved for the treatment of HIV. It is a nucleoside analog reverse transcriptase inhibitor, or nuke. These drugs block the reverse transcriptase enzyme. This enzyme changes HIV's genetic material (RNA) into the form of DNA. This has to occur before HIV's genetic code gets inserted into an infected cell's own genetic codes."
http://www.thebody.com/nmai/azt.html

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Zidovudine for the Prevention of HIV Transmission from Mother to Infant, 04/29/1994, CDC Wonder:"Worldwide, perinatal (i.e., mother to infant) transmission accounts for most human immunodeficiency virus (HIV) infections among children; in the United States, of the approximately 7000 infants born to HIV-infected mothers each year, 1000-2000 are HIV-infected (1). Strategies for reducing perinatally acquired HIV infection have included preventing HIV infection among women and, for HIV-infected women, avoiding pregnancy or refraining from breastfeeding their infants (2). On February 21, 1994, the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) and National Institute of Child Health and Human Development (NICHD) announced preliminary results from a randomized, multicenter, double-blinded clinical trial of zidovudine (ZDV) to prevent HIV transmission from mothers to their infants (AIDS Clinical Trials Group {ACTG} protocol 076)."
http://wonder.cdc.gov/wonder/prevguid/m0030635/m0030635.asp

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Zidovudine (Systemic), Description, MEDLINEplus:"Zidovudine (zye-DOE-vue-deen) (also known as AZT) is used, alone or together with zalcitabine (ddC), in the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus responsible for acquired immune deficiency syndrome (AIDS). Zidovudine is used to slow the progression of disease in patients infected with HIV who have advanced symptoms, early symptoms, or no symptoms at all. This medicine also is used to help prevent pregnant women who have HIV from passing the virus to their babies during pregnancy and at birth."
Office of Communications and Public Liaison National Library of Medicine
8600 Rockville Pike Bethesda, Maryland 20894
Phone: (301) 496-6308 Fax: (301) 496-4450 email: publicinfo@nlm.nih.gov
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a687007.html

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Zidovudine, Indications, Parsdarou.com:"Human immundodeficiency virus (HIV) infection, asymptomatic (treatment) or acquired immunodeficiency syndrome (AIDS) (treatment)- Zidovudine is indicated as a primary agent in the treatment of human immunodeficiency virus(HIV)disease in adult patients with a CD4 lymphocyte count of 500 per mm³ or less who are asymptomatic, who have early symptoms of HIV disease, or who have advance symptoms of HIV disease (AIDS)."
http://www.parsdarou.com/drugs/Zidovudine.htm

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Zidovudine, Description, RXlist:"WARNING: RETROVIR (ZIDOVUDINE) MAY BE ASSOCIATED WITH HEMATOLOGIC TOXICITY INCLUDING GRANULOCYTOPENIA AND SEVERE ANEMIA PARTICULARLY IN PATIENTS WITH ADVANCED HIV DISEASE (SEE WARNINGS). PROLONGED USE OF RETROVIR HAS BEEN ASSOCIATED WITH SYMPTOMATIC MYOPATHY SIMILAR TO T.A PRODUCED BY HUMAN IMMUNODEFICIENCY VIRUS."
WebMD
Attn: Office of Privacy
1175 Peachtree Street, NE
Suite 2400
Atlanta, GA 30361
Or call: 866-788-3097
http://www.rxlist.com/cgi/generic3/zidovud.htm

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Zidovudine, Tiscali Reference:"Antiviral drug used in the treatment of AIDS . It is not a cure for AIDS but is effective in prolonging life it does not, however, delay the onset of AIDS in people carrying the virus.

Zidovudine was developed in the mid-1980s and approved for use by 1987. Taken every four hours, night and day, it reduces the risk of opportunistic infection and relieves many neurological complications. However, frequent blood monitoring is required to control anaemia, a potentially life-threatening side effect of zidovudine. Blood transfusions are often necessary, and the drug must be withdrawn if bone-marrow function is severely affected."
http://www.tiscali.co.uk/reference/encyclopaedia/hutchinson/m0027020.html

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