Nursing & Healthcare Directories on: The Nursefriendly
Benzodiazepines, Anticonvulsants
Klonopin, Clonezapam

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Doctors' Answers to "Frequently Asked Questions" - Klonopin:"These comments are made for the purpose of discussion and should NOT be used as recommendations for or against therapies or other treatments. An individual patient is always advised to consult their own physician."
http://www.druginfonet.com/faq/faqklon.htm

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Klonopin, Druginfo.net:"Klonopin is useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. In patients with absence seizures (petit mal) who have failed to respond to succinimides, Klonopin may be useful."
http://www.druginfonet.com/klonopin.htm

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Clonazepam in the treatment of panic disorder with or without agoraphobia, Rosenbaum JF, Moroz G, Bowden CL, The Good Drug Guide:"In this multicenter, parallel-group, placebo-controlled, fixed-dose study, the efficacy, safety, dosing characteristics, and discontinuation of clonazepam were analyzed in patients with panic disorder. Four hundred thirteen patients were randomly assigned to receive placebo or one of five fixed daily doses of clonazepam (0.5 mg, 1.0 mg, 2.0 mg, 3.0 mg, and 4.0 mg). After 3 weeks of dose escalation, the fixed dose was given for 6 weeks (the dose-maintenance phase) and then was tapered during a 7-week discontinuance phase."
http://www.biopsychiatry.com/clonazepam.html

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Klonopin, Why Is This Drug Prescribed, Healthsquare.com:"Klonopin is used alone or along with other medications to treat convulsive disorders such as epilepsy. It is also prescribed for panic disorder--unexpected attacks of overwhelming panic accompanied by fear of recurrence. Klonopin belongs to a class of drugs known as benzodiazepines."
http://www.healthsquare.com/newrx/KLO1214.HTM

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Clonazepam, Brand Name: Klonopin, Rivotril, Pharmacology, Internet Mental Health:"Clonazepam's pharmacological profile is similar to other anxiolytic/sedative benzodiazepines. Its basic anticonvulsive properties are also similar to those of other diazepines. Clonazepam is capable of suppressing the spike and wave discharge in absence seizures (petit mal) and decreasing the frequency, amplitude, duration and spread of discharge in minor motor seizures. Clonazepam is well absorbed orally with maximum blood concentrations occurring in 1 to 2 hours. Clonazepam is metabolized by the liver to inactive metabolites, which are excreted mainly in the urine. Less than 0.5% of a dose is excreted in the urine unchanged and from 9 to 27% of a dose may be excreted in the feces. The half-life of the parent compound varies from approximately 18 to 50 hours."
http://www.mentalhealth.com/drug/p30-r04.html

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Klonopin, Warnings, PSYweb.com:"Narcotics may increase the sedative effects of this drug. Do not take other sedative, benzodiazepines, or sleeping pills with this drug. The combinations could be fatal. Do not drink alcohol when taking benzodiazepines. Alcohol can lower blood pressure and decrease your breathing rate to the point of unconsciousness. The habit-forming potential is high. Psychological and physical dependence is common. It is possible to become dependent in only two to four weeks. If used for anti-anxiety treatment: This drugs should not be taken for more then four weeks ( Yudofsky, Hales and Ferguson . ) Do not stop taking this drug abruptly, this could cause psychological and physical withdrawal symptoms."
http://www.psyweb.com/Drughtm/klonopin.html

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Klonopin brand of clonezepam tablets, Pharmacodynamics, Roche Pharmaceuticals:"The precise mechanism by which clonazepam exerts its antiseizure and antipanic effects is unknown, although it is believed to be related to its ability to enhance the activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Convulsions produced in rodents by pentylenetetrazol or, to a lesser extent, electrical stimulation are antagonized, as are convulsions produced by photic stimulation in susceptible baboons. A taming effect in aggressive primates, muscle weakness and hypnosis are also produced. In humans, clonazepam is capable of suppressing the spike and wave discharge in absence seizures (petit mal) and decreasing the frequency, amplitude, duration and spread of discharge in minor motor seizures."
http://www.rocheusa.com/products/klonopin/

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Klonopin, RX List Monographs:"Epilepsy, absence; Epilepsy, akinetic; Epilepsy, myoclonic; Lennox-Gastaut syndrome; DEA Class CIV; FDA Approved 1975 Jun; Top 200 Drugs; Pregnancy Category D; WHO Formulary; Orphan Drugs."
http://www.rxlist.com/cgi/generic/clonaz.htm

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This page was created on Wednesday, November 8, 2000

Last updated by Andrew Lopez, RN on Monday, November 22, 2010


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