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Sertraline Drug monograph, Pharmacology, Internet Mental Health:"The antidepressant effect of sertraline is presumed to be linked to its ability to inhibit the neuronal reuptake of serotonin. It has only very weak effects on norepinephrine and dopamine neuronal reuptake. At clinical doses, sertraline blocks the uptake of serotonin into human platelets. Like most clinically effective antidepressants, sertraline downregulates brain norepinephrine and serotonin receptors in animals. In receptor binding studies, sertraline has no significant affinity for adrenergic (alpha(1), alpha(2) and beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5-HT1A, 5-HT1B, 5-HT2) or benzodiazepine binding sites. In placebo-controlled studies in normal volunteers, sertraline did not cause sedation and did not interfere with psychomotor performance."
http://www.mentalhealth.com/drug/p30-z02.html

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Zoloft, National Alliance for the Mentally Ill:"What are the side effects? The most common side effects of Zoloft include nausea, diarrhea or loose stools, tremor, insomnia, drowsiness, and dry mouth. These are usually mild; only a small number of patients have discontinued treatment because of side effects. Other potential side effects include increased sweating and sexual problems (delayed ejaculation/orgasm). Although older antidepressants often cause weight gain, 1-2 pound weight loss has been noticed in some people. Zoloft does not seem to cause dizziness upon standing up, and has few cardiac effects."
National Alliance for the Mentally Ill
Colonial Place Three, 2107 Wilson Blvd., Suite 300, Arlington, VA 22201
Phone: 703-524-7600; NAMI HelpLine: 1-800-950-NAMI [6264]
http://www.nami.org/helpline/zoloft.htm

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Sertraline ( Zoloft ):"Sertraline ( Zoloft ) is used in the treatment of all types of depression. It may also be used to panic disorder, social phobia, obesity, or obsessive-compulsive disorder ( OCD )."
http://www.psyweb.com/Drughtm/sertra.html

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ZOLOFT® (sertraline hydrochloride):" Sertraline HCl is a selective serotonin reuptake inhibitor (SSRI) for oral administration. It is chemically unrelated to other SSRIs, tricyclic, tetracyclic, or other available antidepressant agents. It has a molecular weight of 342.7. Sertraline hydrochloride has the following chemical name: (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-nanphthalenamine hydrochloride. The empirical formula is C17H17NCl2·HCl."
http://www.rxlist.com/cgi/generic/sertral.htm

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Zoloft Sertraline, Whatmeds.com:"Overview Zoloft is the brand name for Sertraline, and antidepressant, antiobsessional, and antipanic agent. It is an SSRI - Selective Serotonin Reuptake Inhibitor, which is a class of drugs that increase the levels of serotonin in a patient. Zoloft may take effect in one to three weeks or more."
http://www.whatmeds.com/meds/zoloft.html

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Articles:

Newly Approved Drug Therapies:
http://www.centerwatch.com/drugs/DRU292.HTM

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