Paxil (paroxetine hydrochloride), Centerwatch.com:"Paxil has been approved for the treatment of panic disorder, a disabling condition that will affect three to six million Americans at some time in their lives. Paxil belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). For many years, the only drug indicated for panic disorder was the benzodiazepine tranquilizer alprazolam. However, alprazolam is associated with dependence and is not indicated for long-term treatment of this chronic condition. Paxil has not been associated with the development of dependence in clinical trials and is indicated for long-term treatment of panic disorder."
Thomson CenterWatch
22 Thomson Place, 47F1 Boston, MA 02210-1212
Phone: 617-856-5900 Fax: 617-856-5901
customerservice@ahcpub.com
http://www.centerwatch.com/drug-information/fda-approvals/drug-details.aspx?DrugID=104

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Paxil (paroxetine hydrochloride), healthyplace.com:"Paxil (paroxetine hydrochloride) is an orally administered antidepressant with a chemical structure unrelated to other selective serotonin reuptake inhibitors or to tricyclic, tetracyclic or other available antidepressant agents. The antidepressant action of paroxetine and its efficacy in the treatment of obsessive compulsive disorder (OCD) and panic disorder (PD) is presumed to be linked to potentiation of serotonergic activity in the central nervous system resulting from inhibition of neuronal reuptake of serotonin."
HealthyPlace.com, Inc
General Inquiries: info@healthyplace.com
Phone 210-225-4388 (Office)
http://www.healthyplace.com/medications/paroxetine.htm

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Paxil, Antidepressant, National Alliance For The Mentally Ill (NAMI):"Paxil is as effective in relieving depression as TCAs such as imipramine. However, Paxil causes fewer adverse cardiovascular and anticholinergic effects (dry mouth, constipation, blurred vision, urinary retention) than the older TCAs. It does not usually cause drowsiness, low blood pressure, or weight changes. Paxil has no active metabolites and leaves one's system 24 hours after it enters. SmithKline Beecham Pharmaceuticals, which makes Paxil, states that Paxil is the most selective of the SSRI antidepressants. This selectivity causes serotonin levels in the brain to normalize quickly, relieving depression with relatively few side effects."
http://www.nami.org/Template.cfm?Section=About_Medications&Template=/TaggedPage/TaggedPageDisplay.cfm&TPLID=51&ContentID=20818

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Paroxetine, rxlist.com:"The antidepressant action of paroxetine (and, for the immediate-release tablets and oral suspension, its efficacy in the treatment of social anxiety disorder (for the immediate-release formulations), obsessive compulsive disorder [OCD], and panic disorder [PD]) is presumed to be linked to potentiation of serotonergic activity in the central nervous system resulting from inhibition of neuronal reuptake of serotonin (5-hydroxy-tryptamine, 5-HT). Studies at clinically relevant doses in humans have demonstrated that paroxetine blocks the uptake of serotonin into human platelets. In vitro studies in animals also suggest that paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. In vitro radioligand binding studies indicate that paroxetine has little affinity for muscarinic, alpha1-, alpha2-, beta-adrenergic-, dopamine (D2)-, 5-HT1-, 5-HT2- and histamine (H1)-receptors; antagonism of muscarinic, histaminergic and alpha1-adrenergic receptors has been associated with various anticholinergic, sedative and cardiovascular effects for other psychotropic drugs."
WebMD
Attn: Office of Privacy
1175 Peachtree Street, NE
Suite 2400
Atlanta, GA 30361
Or call: 866-788-3097
http://www.rxlist.com/paxil-drug.htm#cp

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Paroxetine: Drug monograph, Mentalhealth.com:"Paroxetine is a potent and selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor (SSRI). This activity of the drug on brain neurons is thought to be responsible for its antidepressant effects. Paroxetine is a phenylpiperidine derivative which is chemically unrelated to the tricyclic or tetracyclic antidepressants. In receptor binding studies, paroxetine did not exhibit significant affinity for the adrenergic (alpha(1), alpha(2), beta), dopaminergic, serotonergic (5HT(1), 5HT(2)), or histaminergic receptors of rat brain membrane. A weak affinity for the muscarinic acetylcholine receptor was evident. The predominant metabolites of paroxetine are essentially inactive as 5-HT reuptake inhibitors."
http://www.mentalhealth.com/drug/p30-p02.html

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PaxilCR.com:"Millions of people have anxiety disorders, like panic and social anxiety disorders, and depression. And there are millions of women who suffer from premenstrual dysphoric disorder (PMDD). Too many of them are still waiting to feel relief. "
http://www.paxilcr.com

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Articles:

Paxil, First Antidepressant Cleared by FDA for Panic Disorder:
http://www.pslgroup.com/dg/84b2.htm

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Paxil Approved in the U.K. for the Treatment of Panic Disorder:"SmithKline Beecham (NYSE: SBE, SBH) announced today that Paxil(TM) (paroxetine HCl), the antidepressant, has been approved by health authorities in the United Kingdom for the treatment of panic disorder, the main symptoms of which are panic attacks. Paxil, which is marketed under the tradename Seroxat(TM) in the U.K., is currently the only selective serotonin re- uptake inhibitor in the U.K. to have an indication for this disorder. Sufferers from panic disorder experience brief, recurring episodes of intense fear, often accompanied by multiple physical symptoms such as chest pains, palpitations and difficulty in breathing. Although symptoms are short-lived, the sufferer may continue to feel distressed for some time afterwards. Panic attacks are usually sudden and unexpected and can have an immediate devastating impact on sufferers, who often fear they are dying, or, at the very least, are seriously ill."
http://www.pslgroup.com/dg951121a.htm

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Associations:

National Alliance for the Mentally Ill:
http://www.nami.org/index.html

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PAXIL WARNING, Leflaw.net:"As patients like Melissa attempt to discontinue use of various antidepressants, some experts worry they are not getting enough information about how to deal with potential withdrawal side effects. Millions of people, perhaps as many as 10 percent of the American population, have taken serotonin boosters, which are often used to treat depression, panic disorder and compulsive behavior. Many of them have no problem discontinuing use, but others experience side effects of varying degrees."
http://lawtomation.com/leflawnet/paxil/

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