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Painkillers, Analgesics, Pain Relievers,
Almotriptan, Axert, Migraine Headache Pain Relief

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This page was prepared by Lynn Kash, RN, Internet Nursing Guide
Pennsylvania Nurses,Emergency Department
http://www.nursefriendly.com/kash/

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AHS: Early Almotriptan (Axert) Migraine Treatment Gets Best Pain-free Response, June 23, 2002, Doctor's Guide:"Initiating migraine treatment with almotriptan (Axert) within the first hour of attack onset offers the best possibility of attaining a pain-free response, researchers reported here June 22 at the annual meeting of the American Headache Society."
http://www.pslgroup.com/dg/2167d6.htm

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Almotriptan, Who is this for, Drug Digest:"Almotriptan belongs to a class of drugs variously called 5HT receptor agonists, selective serotonin receptor agonists, or "triptans." It is used to treat migraine headaches in adults. It cannot prevent migraine attacks from occurring.

Almotriptan is approved only for treating migraines that have already started. It has not been tested for cluster headaches, basilar or hemiplegic migraines, or any other type of headache."
http://www.drugdigest.org/DD/DVH/Uses/0,3915,550245%7CAlmotriptan,00.html

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ALMOTRIPTAN, What are almotriptan, Drugs.com:"Almotriptan is a headache medicine. It is in a class of drugs called serotonin receptor agonists. They are believed to work by causing vasoconstriction (narrowing) of arteries and veins that supply blood to the head."
http://www.drugs.com/xq/cfm/pageID_0/htm_d04757A1.htm/bn_almotriptan/qx/index.htm

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Axert, Most important fact about this drug, Health Square:"In people with heart disease, this type of drug has been known to trigger irregular heartbeat and heart attacks, sometimes leading to death. Do not take this medication if you have angina, a history of heart attack, or any other serious heart problem."
http://www.healthsquare.com/newrx/axe1583.htm

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Almotriptan (Systemic), Description, MEDLINEplus:"Almotriptan ( al-moh-TRIP-tan) is used to treat severe migraine headaches. Many people find that their headaches go away completely after they take almotriptan. Other people find that their headaches are much less painful, and that they are able to go back to their normal activities even though their headaches are not completely gone. Almotriptan often relieves other symptoms that occur together with a migraine headache, such as nausea, vomiting, sensitivity to light, and sensitivity to sound."
U.S. National Library of Medicine
8600 Rockville Pike, Bethesda, MD 20894
custserv@nlm.nih.gov
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/500301.html

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AXERT® (almotriptan malate tablets), FDA Approves AXERT™™ for Acute Treatment of Migraine, May 7, 2001, Migraines.org:" Pharmacia Corporation announced today that the U.S. Food and Drug Administration (FDA) has approved AXERT™ (almotriptan malate tablets) for the acute treatment of Migraine with or without aura in adults. MAGNUM spoke with Pharmacia at Headache 2000 in London, England last year about their new treatment, and where impressed both with papers regarding almotriptan and with the willingness of the makers to address Migraine disease patient awareness when marketing this new treatment."
http://www.migraines.org/treatment/proaxert.htm

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Almotriptan [Axert], A "triptan" for migraine, Pharmacology for Nursing Care:"Almotriptan [Axert] is indicated for oral therapy of an ongoing migraine attack. The drug is similar to sumatriptan (pages 225-226) with respect to mechanism, efficacy, time course, and adverse effects. However, almotriptan differs from sumatriptan as well as other triptans in that it is less likely to cause tightness in the chest, throat, and neck, and hence is better tolerated. Nonetheless, like other triptans, almotriptan can cause coronary vasospasm, and hence is contraindicated for patients with ischemic heart disease, prior MI, or uncontrolled hypertension. To avoid excessive vasospasm, almotriptan should not be administered within 24 hours of an ergot alkaloid or another triptan. In contrast to other triptans, almotriptan can be used safely in combination with an MAO inhibitor."
http://www1.us.elsevierhealth.com:8300/SIMON/Lehne/newsletter/newsletter2.html

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Axert, Why is this drug prescribed, PDR.net:"Axert is a migraine treatment. It relieves the type of migraine that's accompanied by an aura (a set of symptoms that includes visual disturbances, speech difficulties, tingling, numbness, and weakness), as well as the kind that lacks an aura.

Axert is a member of a family of drugs called selective serotonin receptor agonists. These medications are thought to work by stopping abnormal dilation of blood vessels in the head, fighting inflammation, and reducing pain transmissions along certain nerve pathways near the brain."
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/axe1583.shtml

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Axert etc. (Almotriptan malate), Remedyfind.com:"Axert etc. (Almotriptan malate) is a new selective serotonin 5-HT receptor agonist medication used to treat migraine attacks with or without aura. Many experts believe that serotonin agonists relieve migraine headache by constricting swollen cranial blood vessels, thereby reducing inflammation around the vessels and reducing pain. Serotonin agonists are also known as "triptans'."
http://remedyfind.com/rm-621-Axert.asp

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Almotriptan, Indications, RXlist:"AXERT Tablets are indicated for the acute treatment of migraine with or without aura in adults.

AXERT is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). Safety and effectiveness of AXERT have not been established for cluster headache, which is present in an older, predominantly male population."
http://www.rxlist.com/cgi/generic2/almotriptan_ids.htm

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Last updated by Andrew Lopez, RN on Monday, November 22, 2010


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