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Diet Pills, Weight Loss, Appetite Supressants,
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Immediate release tablets containing 20 mg fenfluramine hydrochloride are orange, scored, compressed tablets engraved AHR and 6447." http://www.rxlist.com/cgi/generic/fenflur.htm ****************************************************** Fenfluramine Hydrochloride, Contraindications, InChem.org:"Anorexia, insomnia, psychopathic personality disorders, suicidal tendencies, Gilles de la Tourette syndrome and other disorders, hyperthyroidism, narrow angle glaucoma, diabetes mellitis and cardiovascular diseases such as angina, hypertension and arrythmias (Dollery, 1991; Reynolds, 1996). " http://www.inchem.org/documents/pims/pharm/pim938.htm#SectionTitle:4.1%20%20Indications ****************************************************** Fenfluramine Hydrochloride, Cardiotoxic effects of fenfluramine hydrochloride, Fen-Phen-eResource :"The cardiotoxic effects of fenfluramine hydrochloride on mechanical and electrical activity were studied in papillary muscles, Purkinje fibres, left atria and ventricular myocytes of guinea-pigs. Force of contraction (fc) was measured isometrically, action potentials and maximum rate of rise of the action potential (Vmax) were recorded by means of the intracellular microelectrode technique and the sodium current (INa) with patch-clamp technique in the cell-attached mode." http://www.fen-phen-eresource.com/article352.cfm ****************************************************** Fenfluramine Hydrochloride, Echocardiographic Examination of Women Previously Treated With Fenfluramine, June 11, 2001, Archives of Internal Medicine:"Fenfluramine hydrochloride was withdrawn from the market in September 1997 after reports of heart valve abnormalities in patients who used it. The prevalence of echocardiographic abnormalities and the clinical cardiovascular status of patients who received fenfluramine monotherapy remains uncertain." http://archinte.ama-assn.org/issues/v161n11/abs/ioi00479.html ****************************************************** Fenfluramine Hydrochloride(Pondimin), Letter Removing Pondimin From the Market, Pondimin Lawyer Network:"Additional adverse event reports of abnormal heart valve findings in patients using dexfenfluramine or fenfluramine alone or in combination with other weight loss agents continue to be received by the company and the FDA. These reports have included dyspnea, chest pain, syncope, lower extremity edema, or a new heart murmur." http://www.pondimin-lawsuit-lawyer.com/page2.php ****************************************************** Fenfluramine Hydrochloride(Pondimin), Pulmonary Hypertension, Best Health Guide:"The link to diet drugs was first recognized in 1967 when there was an epidemic of pulmonary hypertension in Europe among people who had used the appetite suppressant aminorex fumarate (Menocil). In1997, two diet drugs fenfluramine hydrochloride (Pondimin) and dexfenfluramine hydrochloride (Redux)were taken off the market after they, too, were associated with an increased risk for pulmonary hypertension." http://praxis.md/bhg/bhg.asp?chapter=BHG01CA11§ion=report ****************************************************** Fenfluramine Hydrochloride(Pondimin), Report every adverse drug reaction, April 1997, Postgraduate Medicine:"Tomorrow's headlines may well be about the deadly "serotonin syndrome," which looks something like toxic shock. It is triggered when a serotonergic agent, such as fenfluramine hydrochloride (Pondimin), is taken along with another serotonergic agent. Among the many serotonergics are dextromethorphan (an ingredient in various popular over-the-counter cough medicines), melatonin, several of the antidepressants (monoamine oxidase inhibitors, selective serotonin reuptake inhibitors), and many other commonly used drugs (eg, amphetamines, antiparkinson agents, l-tryptophan, lithium, yohimbine hydrochloride) and herbs, such as Saint-John's-wort, which is contained in some herbal teas and other herbal compounds." http://www.postgradmed.com/issues/1997/04_97/ed_apr.htm ****************************************************** Fenfluramine Hydrochloride, Valvular heart disease associated with fenfluramine-phentermine, July 8, 1997, Health Story Page:"These causes raise concern that fenfluramine-phentermine therapy has important implications regarding valvular heart disease. The mechanism of valve injury is uncertain but may be related to an alteration in circulating serotonin. Candidates for fenfluramine-phentermine therapy should be informed about serious potential adverse effects, including pulmonary hypertension and valvular heart disease." http://www.cnn.com/HEALTH/9707/08/fenphen.report/ ****************************************************** Fenfluramine Hydrochloride(Pondimin), Health Pamphlets, Health Link:"The manufacturer of the weight loss drug Pondimin (fenfluramine hydrochloride) have added a new warning regarding a potentially serious and unusual form of valvular heart disease which has been reported in patients taking this drug in combination with phenteramine. The symptoms experienced include shortness of breath, reduced tolerance for exercise, and swelling of the legs. 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