Nursing & Healthcare Directories on: The Nursefriendly
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Anticonvulsant, Antiseizure, Antiepilectic
Dilantin, Phenytoin

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Phenytoin, Brand name: Dilantin, Internet Mental Health:"Phenytoin is an anticonvulsant drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Phenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures."
http://www.mentalhealth.com/drug/p30-d05.html

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Dilantin® Phenytoin Sodium Injection, (USP), oralchelation.com:"There have been a number of reports suggesting a relationship between phenytoin and the development of lymphadenopathy (local or generalized) including benign lymph node hyperplasia, pseudolymphoma, lymphoma, and Hodgkin’s disease. Although a cause and effect relationship has not been established, the occurrence of lymphadenopathy indicates the need to differentiate such a condition from other types of lymph node pathology. Lymph node involvement may occur with or without symptoms and signs resembling serum sickness, eg, fever, rash, and liver involvement."
http://www.oralchelation.com/faq/dilantin1.htm

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Phenytoin, Dilantin, Personal Health Zone:"Phenytoin Related Drugs: Ethotoin, Mephenytoin, Phenytoin Sodium, Extended, Phenytoin Sodium, Prompt, Trade Names: Dilantin Infatab, Dilantin-125 Oral Suspension:"Phenytoin is well known to cause bone problems, including rickets in children and osteoporosis in adults. Although there are undoubtedly several factors at work (see vitamin D and vitamin K below), phenytoin's impairment of calcium absorption is believed to be one of the most important.1,2 Taking calcium supplements should help decrease the risk of bone problems. However, because calcium might reduce the absorption of phenytoin, you should not take calcium during the 2 hours before or after your phenytoin dose.3"
http://www.personalhealthzone.com/pg000364.html

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Phenytoin, Rxlist.com:"Phenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Phenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures."
http://www.rxlist.com/cgi/generic/phenyt.htm

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Sodium Phenytoin, Dilantin, Dephenylhydantoin, Complementary and Alternative Healing University:"This drug is effective for serious seizure attacks and not effective for mild attacks. It takes several days for it to reach the effective concentration in the brain tissue, so the therapeutic effect is not immediate. It is necessary to take it for several days before the effectiveness shows. To control symptoms, phenobarbital is being used as the main drug, but to prevent attacks and for maintenance, sodium phenytoin (Dilantin) is a better selection."
http://alternativehealing.org/dilantin.htm

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DILANTIN (Phenytoin-Generic):"Dilantin is an anti-epileptic drug that has been used to treat patients with epilepsy since 1938. It is helpful in the treatment of Partial Seizures and Generalized Tonic-Clonic Seizures"
http://www.med.umich.edu/neuro/epilepsy/prescriptdrugs/dilantin.htm

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